GELDERN, Thomas W.von : rechercher sur Z-Library

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1

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Gloria von Geldern, Thomas McPharlin, Kyra Becker

Journal:

Neurotherapeutics

Année:

2012

Langue:

english

Fichier:

PDF, 467 KB

english, 2012

2

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 317 KB

english, 2005

3

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Keenan, Martine, Abbott, Michael J., Alexander, Paul W., Armstrong, Tanya, Best, Wayne M., Berven, Bradley, Botero, Adriana, Chaplin, Jason H., Charman, Susan A., Chatelain, Eric, von Geldern, Thomas

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 522 KB

english, 2012

4

Novel p -Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Liu, Gang, Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B., Okasinski, Gregory F., Fesik, Stephen W., von Geldern, Thomas W.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 440 KB

english, 2001

5

Nucleophilic substitution with inversion of configuration at the nucleophile

Heathcock, Clayton H., Von Geldern, Thomas W., Lebrilla, Carlito B., Maier, Wilhelm F.

Journal:

Journal of Organic Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 635 KB

english, 1985

6

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies

WESSALE, Jerry L., ADLER, Andrew L., NOVOSAD, Eugene I., CALZADILLA, Samuel V., DAYTON, Brian D., MARSH, Kennan C., WINN, Martin, JAE, Hwan-Soo, GELDERN, Thomas W.von, OPGENORTH, Terry J., WU-WONG, J.

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 164 KB

english, 2002

7

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies

WU-WONG, J. Ruth, DIXON, Douglas B., CHIOU, William J., SORENSEN, Brian K., LIU, Gang, JAE, H.-S., TASKER, Andrew, GELDERN, Thomas W. Von, WINN, Martin, OPGENORTH, Terry J.

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 120 KB

english, 2002

8

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Strue

Journal:

PLoS Neglected Tropical Diseases

Année:

2019

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2019

9

An Evaluation of a C-Glucuronide as a Liver Targeting Group: Conjugate of a Glucocorticoid Antagonist.

Bryan K. Sorensen, J. T. Link, Thomas von Geldern, Maurice Emery, Jiahong Wang, Bach Hickman, Marlena Grynfard, Annika Goos-Nilsson, Sherry Carroll

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 155 KB

english, 2003

10

Synthesis and Biological Evaluation of Novel, Selective, Nonsteroidal Glucocorticoid Receptor Antagonists.

Irini Akritopoulou-Zanze, Jyoti R. Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K. Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W. von Geldern, Philip R. Kym

Journal:

Année:

2004

Fichier:

PDF, 131 KB

2004

11

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes.

Thomas W von Geldern, et al. et al.

Journal:

Année:

2004

Fichier:

PDF, 10 KB

2004

12

The Synthesis and Characterization of a Novel Insulin Sensitizing Agent.

Thomas W. von Geldern, Regina P. Brun, Masha Kalmanovich, Denise Wilcox, Peer B. Jacobson

Journal:

Année:

2004

Fichier:

PDF, 16 KB

2004

13

Amino-Substituted Heterocycles as Isosteres of trans-Cinnamides: Design and Synthesis of Heterocyclic Biaryl Sulfides as Potent Antagonists of LFA-1/ICAM-1 Binding.

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Année:

2005

Fichier:

PDF, 17 KB

2005

14

“The next big thing” in diabetes: clinical progress on DPP-IV inhibitors

Thomas W. von Geldern, James M. Trevillyan

Journal:

Drug Development Research

Année:

2006

Langue:

english

Fichier:

PDF, 214 KB

english, 2006

15

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Irini Akritopoulou-Zanze, Jyoti R Patel, Kresna Hartandi, Jehrod Brenneman, Martin Winn, John K Pratt, Marlene Grynfarb, Annika Goos-Nisson, Thomas W von Geldern, Philip R Kym

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 279 KB

english, 2004

16

Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator–statin hybrids

J.T Link, Bryan K Sorensen, Chunqiu Lai, Jiahong Wang, Steven Fung, Daisy Deng, Maurice Emery, Sherry Carroll, Marlena Grynfarb, Annika Goos-Nilsson, Thomas von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 302 KB

english, 2004

17

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Elizabeth H. Fry, Charles Hutchins, Celerino Abad-Zapatero, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 199 KB

english, 2006

18

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Thomas W. von Geldern, Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Chaohong Sun, Elizabeth H. Fry, Celerino Abad-Zapatero

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 261 KB

english, 2006

19

Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists

Steven J. Richards, Thomas W. von Geldern, Peer Jacobson, Denise Wilcox, Phong Nguyen, Lars Öhman, Marie Österlund, Birgitta Gelius, Marlena Grynfarb, Annika Goos-Nilsson, Jiahong Wang, Steven Fung, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 173 KB

english, 2006

20

Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists

Bradley J. Backes, Gregory L. Hamilton, Phong Nguyen, Denise Wilcox, Steven Fung, Jiahong Wang, Marlena Grynfarb, Annika Goos-Nilsson, Peer B. Jacobson, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 217 KB

english, 2007

21

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

Bradley J. Backes, Kenton Longenecker, Gregory L. Hamilton, Kent Stewart, Chunqiu Lai, Hana Kopecka, Thomas W. von Geldern, David J. Madar, Zhonghua Pei, Thomas H. Lubben, Bradley A. Zinker, Zhenping

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 409 KB

english, 2007

22

An Evaluation of a C-Glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist

Bryan K. Sorensen, J.T. Link, Thomas von Geldern, Maurice Emery, Jiahong Wang, Bach Hickman, Marlena Grynfarb, Annika Goos-Nilsson, Sherry Carroll

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 152 KB

english, 2003

23

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ETA receptor selectivity

Steven A Boyd, Robert A Mantei, Andrew S Tasker, Gang Liu, Bryan K Sorensen, Kenneth J Henry Jr, Thomas W von Geldern, Martin Winn, Jinshyun R Wu-Wong, William J Chiou, Douglas B Dixon, Charles W Hutc

Journal:

Bioorganic & Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 234 KB

english, 1999

24

Expression of atrial natriuretic peptide receptor-A antagonizes the mitogen-activated protein kinases (Erk2 and P38MAPK) in cultured human vascular smooth muscle cells

Guru Dutt Sharma, Huong T. Nguyen, Alexander S. Antonov, Ross G. Gerrity, Thomas von Geldern, Kailash N. Pandey

Journal:

Molecular and Cellular Biochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 158 KB

english, 2002

25

A 32-year-old man with relapsing-progressive brainstem symptoms

Helmar C Lehmann, Ulrich R Hengge, Lutz Alswede, Andreas Saleh, Gloria von Geldern, Hans Peter Hartung, Thomas Ruzicka, Bernhard Hemmer

Journal:

The Lancet Neurology

Année:

2006

Langue:

english

Fichier:

PDF, 10.16 MB

english, 2006

26

HPLC and PDMS analysis of cleavage products aid in the design of small, stable ANP analogues

EDWARD M. DEVINE JR., ALEXANDER M. BUKO, STEVEN P. CEPA, STEVEN K. DAVIDSEN, WILLIAM H. HOLLEMAN, CAROL A. MARSELLE, TERRY J. OPGENORTH, TODD W. ROCKWAY, THOMAS W. VON GELDERN

Journal:

Chemical Biology & Drug Design

Année:

1992

Langue:

english

Fichier:

PDF, 501 KB

english, 1992

27

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity

von Geldern, Thomas W., Tasker, Andrew S., Sorensen, Bryan K., Winn, Martin, Szczepankiewicz, Bruce G., Dixon, Douglas B., Chiou, William J., Wang, Liming, Wessale, Jerry L., Adler, Andy

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 260 KB

english, 1999

28

A ring-reversed analog of atrial natriuretic peptide retains receptor binding, guanylate cyclase stimulation

Thomas W. von Geldern, Gerald P. Budzik, Terry P. Dillon

Journal:

Biochemical and Biophysical Research Communications

Année:

1992

Langue:

english

Fichier:

PDF, 362 KB

english, 1992

29

Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line

Christine Delporte, Jacques Winand, Piotr Poloczek, Thomas Von Geldern, Jean Christophe

Journal:

European Journal of Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 786 KB

english, 1992

30

Endothelins and endothelin receptor antagonists: Binding to plasma proteins

Jinshyun R. Wu-Wong, William J. Chiou, Daniel J. Huffman, Martin Winn, Thomas W. von Geldern, Terry J. Opgenorth

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 709 KB

english, 1996

31

The effects of diminishing albumin binding to some Endothelin receptor antagonists

Bruce G. Szczepankiewicz, Radhika B. Bal, Thomas W. von Geldern, Jinshyun R. Wu-Wong, William J. Chiou, Douglas B. Dixon, Terry J. Opgenorth, Daniel J. Hoffman, Anthony J. Borre, Kennan C. Marsh, Bach

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 602 KB

english, 1998

32

Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-α in murine Leydig cells

Ravindra Kumar, Thomas W von Geldern, Roberto A Calle, Kailash N Pandey

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

1997

Langue:

english

Fichier:

PDF, 226 KB

english, 1997

33

Azole Endothelin Antagonists. 3. Using Δ log P as a Tool To Improve Absorption

von Geldern, Thomas W., Hoffman, Daniel J., Kester, Jeffrey A., Nellans, Hugh N., Dayton, Brian D., Calzadilla, Samuel V., Marsh, Kennan C., Hernandez, Lisa, Chiou, William, Dixon, Douglas B., Wu-Wong

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 355 KB

english, 1996

34

New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

Szczepankiewicz, Bruce G., Liu, Gang, Jae, Hwan-Soo, Tasker, Andrew S., Gunawardana, Indrani W., von Geldern, Thomas W., Gwaltney, Stephen L., Wu-Wong, J. Ruth, Gehrke, Laura, Chiou, William J., Credo

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 224 KB

english, 2001

35

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W., Longenecker, Kenton, Pireh, Daisy, Stewart, Kent D., Backes, Bradley J., Lai, Chunqiu, Lubben, Thomas H., Ballaron, Stephen J., Beno, David W. A.,

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 155 KB

english, 2007

36

Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance

Bradley Zinker, Amanda Mika, Phong Nguyen, Denise Wilcox, Lars Öhman, Thomas W. von Geldern, Terry Opgenorth, Peer Jacobson

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 287 KB

english, 2007

37

Synthetic studies on arene-olefin cycloadditions. 10. A concise, stereocontrolled total synthesis of (.+-.)-laurenene

Wender, Paul A., Von Geldern, Thomas W., Levine, Barry H.

Journal:

Journal of the American Chemical Society

Année:

1988

Langue:

english

Fichier:

PDF, 409 KB

english, 1988

38

Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists

Tasker, Andrew S., Sorensen, Bryan K., Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W., Dixon, Douglas B., Chiou, William J., Dayton, Brian D., Calzadila, Samuel, Hernandez, Lisa, Marsh, Kennan C.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 282 KB

english, 1997

39

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 5. Highly Selective, Potent, and Orally Active ET A Antagonists

Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W., Sorensen, Bryan K., Chiou, William J., Nguyen, Bach, Marsh, Kennan C., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 104 KB

english, 2001

40

Azole Endothelin Antagonists. 2. Structure−Activity Studies

von Geldern, Thomas W., Kester, Jeffrey A., Bal, Radhika, Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 380 KB

english, 1996

41

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W., Wiedeman, Paul E., Lubben, Thomas H., Zinker, Bradley A., Stewart, Kent, Ballaron, Stephen J., Stashko, Michael A., Mika, Aman

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 409 KB

english, 2006

42

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 2. Sulfonamide-Based ET A /ET B Mixed Antagonists

Jae, Hwan-Soo, Winn, Martin, Dixon, Douglas B., Marsh, Kennan C., Nguyen, Bach, Opgenorth, Terry J., von Geldern, Thomas W.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 337 KB

english, 1997

43

Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Warnke, Clemens, von Geldern, Gloria, Markwerth, Philipp, Dehmel, Thomas, Hoepner, Robert, Gold, Ralf, Pawlita, Michael, Kümpfel, Tania, Mäurer, Mathias, Stangel, Martin, Wegner, Florian, Hohlfeld, Re

Journal:

Annals of Neurology

Année:

2014

Langue:

english

Fichier:

PDF, 296 KB

english, 2014

44

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes

von Geldern, Thomas W., Tu, Noah, Kym, Philip R., Link, James T., Jae, Hwan-Soo, Lai, Chunqiu, Apelqvist, Theresa, Rhonnstad, Patrik, Hagberg, Lars, Koehler, Konrad, Grynfarb, Marlena, Goos-Nilsson, A

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 551 KB

english, 2004

45

Discovery of ((4 R ,5 S )-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8 H )-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W., Madar, David J., Longenecker, Kenton, Yong, Hong, Lubben, Thomas H., Stewart, Kent D., Zinker, Bradley A., Backes, Bradley J., Judd, Andrew S., Mul

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 190 KB

english, 2006

46

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ET A Antagonist (A-216546)

Liu, Gang, Henry,, Kenneth J., Szczepankiewicz, Bruce G., Winn, Martin, Kozmina, Natasha S., Boyd, Steven A., Wasicak, James, von Geldern, Thomas W., Wu-Wong, Jinshyun R., Chiou, William J., Dixon, Do

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 253 KB

english, 1998

47

Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung

Shiosaki, Kazumi, Tasker, Andrew S., Sullivan, Gerard M., Sorensen, Bryan K., von Geldern, Thomas W., Wu-Wong, Jinshyun R., Marselle, Carol A., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1993

48

Azole Endothelin Antagonists. 1. A Receptor Model Explains an Unusual Structure−Activity Profile

von Geldern, Thomas W., Hutchins, Charles, Kester, Jeffrey A., Wu-Wong, Jinshyun R., Chiou, William, Dixon, Douglas B., Opgenorth, Terry J.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 334 KB

english, 1996

49

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.

Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W., Wiedeman, Paul E., Lubben, Thomas H., Zinker, Bradley A., Stewart, Kent, Ballaron, Stephen J., Stashko, Michael A., Mika, Aman

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 6 KB

english, 2006

50

Small atrial natriuretic peptide analogs: design, synthesis, and structural requirements for guanylate cyclase activation

Von Geldern, Thomas W., Rockway, Todd W., Davidsen, Steven K., Budzik, Gerald P., Bush, Eugene N., Chu-Moyer, Margaret Y., Devine, Edward M., Holleman, William H., Johnson, Marty C.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.86 MB

english, 1992